الاستخدام المتزامن مع أي شكل من النيترات، مثل النيتروجليسرين، والإيزوسوربيد ثنائي النترات، حيث يزيد من احتمالية هبوط الضغط.
İlaçlar ruhsat alıp piyasaya çıkmadan önce kapsamlı klinik araştırmalar ile examination edilmektedir ancak ilacın yaygın olarak veya uzun süreli kullanımında ortaya çıkabilecek yan etkilerden bazıları henüz tespit edilmemiş olabilir.
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